It is possible to know God personally...
Sin causes us to:
Miss God's very best for our life
"Jesus said... I have come that they may have life, and have it to the full." (John 10:10)
Face death and judgement
"For the wages of sin is death, but the gift of God is eternal life in Christ Jesus our Lord." (Romans 6:23)
"He will punish those who do not know God and do not obey the gospel of our Lord Jesus. They will be punished with everlasting destruction and shut out from the presence of the Lord and from the majesty of his power
" (II Thessalonians 1:8-9)
BUT...there is a solution.